<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-5705</journal-id>
<journal-title><![CDATA[Inter disciplina]]></journal-title>
<abbrev-journal-title><![CDATA[Inter disciplina]]></abbrev-journal-title>
<issn>2448-5705</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-57052022000100147</article-id>
<article-id pub-id-type="doi">10.22201/ceiich.24485705e.2022.26.80973</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La obesidad: aspectos fisiopatológicos y clínicos]]></article-title>
<article-title xml:lang="en"><![CDATA[Obesity: pathophysiological and clinical aspects]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kaufer-Horwitz]]></surname>
<given-names><![CDATA[Martha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Hernández]]></surname>
<given-names><![CDATA[Juan Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departamento de Endocrinología y Metabolismo Clínica de Obesidad y Trastornos de la Conducta Alimentaria]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departamento de Endocrinología y Metabolismo Clínica de Obesidad y Trastornos de la Conducta Alimentaria]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>10</volume>
<numero>26</numero>
<fpage>147</fpage>
<lpage>175</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-57052022000100147&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-57052022000100147&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-57052022000100147&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La obesidad es una enfermedad crónica, recurrente, de etiología compleja caracterizada por un desequilibrio de energía debido a un estilo de vida sedentario, un consumo excesivo de energía, o ambos. Se desarrolla a partir de la interacción de factores genéticos, sociales, conductuales, psicológicos, metabólicos, celulares y moleculares. Se define como la acumulación anormal o excesiva de tejido adiposo en relación con el peso que puede ser perjudicial para la salud. Es factor de riesgo de enfermedades crónicas como diabetes mellitus tipo 2, enfermedades cardiovasculares y algunos cánceres y tiene repercusiones biológicas, psicológicas y sociales. Afecta, aunque de manera diferencial, a ambos sexos y a todos los grupos socioeconómicos y de edad. Su prevalencia, tanto a escala mundial como en México, se ha incrementado en los últimos treinta años. Su tratamiento debe ser multidisciplinario siendo el componente central el cambio en el estilo de vida (alimentación y actividad física). En algunos casos la prescripción de fármacos puede ser necesaria como coadyuvante al tratamiento y en casos de obesidad extrema la cirugía bariátrica es la opción más efectiva y se asocia con mejoría metabólica. El presente documento se concentra en el abordaje de los aspectos fisiopatológicos y clínicos más relevantes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Obesity is a chronic, recurrent disease of complex etiology characterized by an imbalance of energy due to a sedentary lifestyle, excessive energy intake, or both. It develops from the interaction of genetic, social, behavioral, psychological, metabolic, cellular and molecular factors. In general terms, it is defined as an abnormal or excessive storage of adipose tissue in relation to weight that may be harmful to health. It is a risk factor for chronic non-communicable diseases such as type 2 diabetes, cardiovascular diseases and different cancers, and has biological, psychological and social repercussions. It affects, although differentially, both genders and all socioeconomic and age groups. Its prevalence, both worldwide and in Mexico, has increased in the last thirty years. Its treatment must be multidisciplinary, being a change in lifestyle (food and physical activity) the central component. In some cases, prescription of specific drugs may be necessary as an adjuvant to treatment and, in cases of extreme obesity, bariatric surgery is the most effective option and is associated with metabolic improvement. This document concentrates on addressing the most relevant pathophysiological and clinical aspects of the disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[comorbilidades]]></kwd>
<kwd lng="es"><![CDATA[dieta]]></kwd>
<kwd lng="es"><![CDATA[estilo de vida]]></kwd>
<kwd lng="es"><![CDATA[tratamiento]]></kwd>
<kwd lng="en"><![CDATA[obesity]]></kwd>
<kwd lng="en"><![CDATA[comorbidities]]></kwd>
<kwd lng="en"><![CDATA[diet]]></kwd>
<kwd lng="en"><![CDATA[lifestyle]]></kwd>
<kwd lng="en"><![CDATA[treatment]]></kwd>
</kwd-group>
</article-meta>
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