<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422017000100006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neurobiología de las adicciones]]></article-title>
<article-title xml:lang="en"><![CDATA[Neurobiology of addictions]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Méndez-Díaz]]></surname>
<given-names><![CDATA[Mónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero Torres]]></surname>
<given-names><![CDATA[Brenda M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortés Morelos]]></surname>
<given-names><![CDATA[Jacqueline]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruíz-Contreras]]></surname>
<given-names><![CDATA[Alejandra E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Prospéro García]]></surname>
<given-names><![CDATA[Oscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UNAM Facultad de Medicina Departamento de Fisiología]]></institution>
<addr-line><![CDATA[Ciudad de Mexico ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNAM Facultad de Medicina Departamento de Psiquiatría y Salud Mental]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,UNAM Facultad de Psicología Laboratorio de Neurogenómica Cognitiva]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2017</year>
</pub-date>
<volume>60</volume>
<numero>1</numero>
<fpage>6</fpage>
<lpage>16</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422017000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422017000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422017000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La proporción de usuarios de una droga de abuso que desarrolla dependencia sólo representa una parte de ellos. Es decir, hay una proporción de usuarios que no presentan un trastorno por consumo de sustancias (TCS). Por ejemplo, en Mexico sólo el 15% de quienes consumen alcohol desarrollan un trastorno por consumo de alcohol (&#1058;&#1057;&#1040;). Este 15% sugiere una vulnerabilidad en esta población, por lo que determinar los mecanismos que predisponen a estos sujetos a la adicción es indispensable para la prevención &#1086; para la rehabilitación del TCS. Se ha sugerido la participación de factores genéticos y medioambientales en el desarrollo de dicha vulnerabilidad al TCS. Por ejemplo, se ha demostrado que los sujetos que son psicópatas o sociópatas &#1091; que son agresivos, que presentan falta de atención y son impulsivos, entre otras características clínicas, presentan comorbilidad con el abuso y dependencia a sustancias. Por otro lado, se ha observado que existe una relación entre las experiencias adversas en los primeros años de vida y el consumo de sustancias de abuso. En estudios preclínicos, hemos demostrado que las ratas privadas de cuidado materno en los días posnatales 2 al 16 (DPN2-DPN16), al llegar a la edad adulta (DPN90) consumen más alcohol que las que han recibido cuidado materno todo el tiempo. Además, presentan una desregulación en la expresión de los receptores para canabinoides del tipo &#1493; (CB1R) en algunas zonas del cerebro, por ejemplo, el núcleo accumbens y la corteza prefrontal. En breve, podríamos suponer que un sujeto es vulnerable a tener una adicción si nace psicópata o desarrolla una personalidad antisocial, o bien, si durante la infancia ha contendido con situaciones adversas, como son un pobre cuidado parental o el abuso verbal, fisco o sexual. Cabe señalar que estos no son los únicos factores que han sido asociados a este trastorno, pero para los fines de esta revisión, sólo discutiremos esta vulnerabilidad con base en los mecanismos epigenéticos que afectan al sistema endocanabinérgico (seCB) e interfieren con la función del sistema de inhibición de la conducta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The proportion of drug abuse users that develop dependence does not represent the totality of users. Therefore, there is a substantial proportion of users that does not develop a substance use disorder (SUD). For example, in Mexico, only 15% of all alcohol consumers develop alcohol use disorder (AUD). Determining the mechanisms that predispose individuals to AUD or SUD is crucial for its prevention or rehabilitation. The involvement of genetic and environmental factors to the development of SUD has been suggested. For example, psychopaths or sociopaths that have a strong genetic predisposition have comorbidity with SUD. On the other hand, a relationship between adverse experiences in the early years of and substance abuse has been documented. In pre-clinical studies, we have shown that rats deprived of maternal care from postnatal day (PND)2 to PND16, and tested once they reach adulthood (PND90) consume more alcohol than those that were under materna care at all times. In addition, we observed a dysregulation in the expression of cannabinoid receptors type 1 (CBIR)in some areas of the brain, i.e. nucleus acumens and prefrontal cortex. In short, we presume that a subject who is vulnerable to addiction has either been born with a psychopathic disorder, developed an antisocial personality, experienced adverse situations such as neglected parental care, or verbal, physical or sexual abuse. These are not the only factors that have been associated with SUD, but for the purposes of this review we will discuss vulnerability based only on epigenetic mechanisms affecting the endocannabinergic system and interfering with the functioning of the behavior inhibition system.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Adicción]]></kwd>
<kwd lng="es"><![CDATA[sistema de endocanabinoides]]></kwd>
<kwd lng="es"><![CDATA[impulsividad]]></kwd>
<kwd lng="es"><![CDATA[psicópata]]></kwd>
<kwd lng="es"><![CDATA[sociópata]]></kwd>
<kwd lng="en"><![CDATA[Addiction]]></kwd>
<kwd lng="en"><![CDATA[endocannabinoid system]]></kwd>
<kwd lng="en"><![CDATA[impulsivity]]></kwd>
<kwd lng="en"><![CDATA[psychopath]]></kwd>
<kwd lng="en"><![CDATA[sociopath]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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